Model-based approaches for modeling response over time in the presence of time trends
Pavla Krotka, Marta Bofill Roig
2022-10-13
1 Methods
- Fixed-effect model with stepwise (period) adjustment
- Fixed-effect model with linear adjustment
- Mixed-effect model with stepwise (period) adjustment
- Local regression (LOESS)
- Generalized additive model with P-splines
- Kernel regression
2 Fitted values - linear trend
2.1 Control response over time
2.2 Response for all arms over time
3 Fitted values - inverted-U trend
3.1 Control response over time
3.2 Response for all arms over time
4 Fitted values - stepwise time trend
4.1 Control response over time
4.2 Response for all arms over time
Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna.
[Klassifizierung: vertraulich]
marta.bofillroig@meduniwien.ac.at
and Pavla Krotka
pavla.krotka@meduniwien.ac.at