1 Methods

  • Fixed-effect model with stepwise (period) adjustment
  • Fixed-effect model with linear adjustment
  • Mixed-effect model with stepwise (period) adjustment
  • Local regression (LOESS)
  • Generalized additive model with P-splines
  • Kernel regression

2 Fitted values - linear trend

2.1 Control response over time

2.2 Response for all arms over time

3 Fitted values - inverted-U trend

3.1 Control response over time

3.2 Response for all arms over time

4 Fitted values - stepwise time trend

4.1 Control response over time

4.2 Response for all arms over time

 

Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna.

[Klassifizierung: vertraulich]

Marta Bofill Roig

marta.bofillroig@meduniwien.ac.at

and Pavla Krotka

pavla.krotka@meduniwien.ac.at