Methods
- Fixed-effect model with stepwise (period) adjustment
- Fixed-effect model with linear adjustment
- Mixed-effect model with stepwise (period) adjustment
- Local regression (LOESS)
- Generalized additive model with P-splines
- Kernel regression
Fitted values - linear
trend
Control response over
time


Response for all arms
over time

Fitted values -
inverted-U trend
Control response over
time


Response for all arms
over time

Fitted values -
stepwise time trend
Control response over
time


Response for all arms
over time

Center for Medical Statistics, Informatics and Intelligent Systems,
Medical University of Vienna.
[Klassifizierung: vertraulich]
Marta Bofill Roig
marta.bofillroig@meduniwien.ac.at
and Pavla Krotka
pavla.krotka@meduniwien.ac.at